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When the keyboard is in Dvorak, [comma] is located where W is in Qwerty. Pressing Command+[comma] to open preferences will open preferences but also seems to bind to Command+W and will close the current editor window. All other keyboard shortcuts seem to work properly. For example, O (Dvorak) is located where S (Qwerty) is. Pressing Command+O will open the Go To Type window but will not save the document. The only difference I can think of is that Preferences is located in the NetBeans menu and not the normal File/Edit/etc menus. (I'm pretty sure this isn't filed in the right place - sorry!)