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Open the Profiling Points window, restart the IDE. In the new IDE session the Add/Edit/Delete/Disable actions of Profiling Points window are enabled just based on the selection, not following the current profiling status.
Fixed by http://hg.netbeans.org/profiler-main/rev/7eca24c9a77e.
Integrated into 'main-silver', will be available in build *201511200002* on http://bits.netbeans.org/dev/nightly/ (upload may still be in progress) Changeset: http://hg.netbeans.org/main-silver/rev/7eca24c9a77e User: Jiri Sedlacek <jis@netbeans.org> Log: Bugfix #256689 - make sure the defaultInstance pointer is updated when restoring persistent Profiling Points window