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 Brompheniramine; Guaifenesin; Hydrocodone: (Major) Concomitant use of hydrocodone with barbiturates may cause respiratory depression, hypotension, profound sedation, and death. Limit the use of opioid pain medications with barbiturates to only patients for whom alternative treatment options are inadequate. It is recommended to avoid this combination when hydrocodone is being used for cough. If concurrent use is necessary, reduce initial dosage and titrate to clinical response; use the lowest effective doses and minimum treatment durations. Educate patients about the risks and symptoms of respiratory depression and sedation. Additionally, concomitant use of hydrocodone with a barbiturate can decrease hydrocodone concentrations; this may result in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical dependence. Monitor for reduced efficacy of hydrocodone and signs of opioid withdrawal. Discontinuation of a barbiturate may increase the risk of opioid-related adverse reactions, such as fatal respiratory depression. Barbiturates induce CYP3A4; hydrocodone is a CYP3A4 substrate. (Moderate) Additive CNS depression may occur if barbiturates are co-used with sedating antihistamines, such as brompheniramine. Monitor for additive CNS and respiratory effects, and warn about the potential effects to driving and other activities.
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 The Cochrane Database of Systematic Reviews conducted a review of topical analgesics. It required at least 50% participant?reported pain relief after appropriate durations. 6 The study identified a number of products that appeared to be effective 6 : In acute musculoskeletal pain, diclofenac gel or plasters, ketoprofen gel, and piroxicam gel provided significantly more relief than the placebo. Adverse event rates with topical NSAIDs were about equivalent to those reported with a topical placebo. High?concentration capsaicin tended to be associated with application-site pain. In chronic musculoskeletal pain (mainly hand and knee osteoarthritis), topical diclofenac and ketoprofen preparations provided significantly more relief than the placebo. Patients were least likely to withdraw from trials for lack of efficacy when diclofenac or salicylates were used. Adverse event withdrawals were higher with low?concentration capsaicin (15%), diclofenac (6%), and salicylates (5%) than the placebo. In postherpetic neuralgia, topical high?concentration capsaicin had limited efficacy for some patients. This study found only limited-, low-, or very low quality evidence of efficacy for other therapies. The researchers concluded that selection of the formulation used influences effectiveness in acute conditions, with gel seemingly more effective. Overall, they found that a small proportion of people experienced good pain relief.
 Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate: (Moderate) Acetaminophen may increase plasma ethinyl estradiol levels, possibly by inhibition of conjugation. Patients taking acetaminophen concomitantly may experience an increase in estrogen related side effects. (Moderate) Barbiturates can accelerate the hepatic clearance of estrogens. For hormonal contraceptives, this interaction could result in unintended pregnancy or breakthrough bleeding. For patients regularly taking a barbiturate, an alternative or back-up method of contraception may be advisable to ensure contraceptive reliability during the use of the barbiturate, and for 1 month following the discontinuation of barbiturate use. Pregnancy has been reported during therapy with both estrogen- and/or progestin-based oral contraceptives in patients receiving barbiturates (e.g., phenobarbital). For patients taking estrogens for other indications, like hormone replacement, monitor the patient for signs and symptoms of reduced therapeutic efficacy or need for dosage adjustment. (Minor) Serum concentrations of caffeine may be increased during concurrent administration with ethinyl estradiol. Patients may desire to limit products that contain high amounts of caffeine to minimize caffeine-related side effects such as nausea or tremors.

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