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 Clonazepam is highly potent and a long-acting benzodiazepine. It exerts its pharmacological effects by acting as a positive allosteric modulator on GABA-A receptors. The GABA-A receptor is a ligand-gated chloride ion-selective channel whose endogenous ligand is GABA (gamma-aminobutyric acid). Benzodiazepines (BZDs) facilitate GABA-A action by increasing the frequency of chloride channel opening resulting in hyperpolarization of the neurons and decreased firing, thus producing calming effects on the brain by reducing the excitability of the neurons.

This information is being provided as a community outreach effort of the College of Psychiatric and Neurologic Pharmacists. This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication. Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions. Never delay seeking professional medical advice or disregard medical professional advice as a result of any information provided herein. The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability alleged as a result of the information provided herein. Once you have detoxed, the best and safest option to get off of and stay off Klonopin and other Benzodiazepines is by the use of one of the many treatment programs we offer at Garden State. We offer many different treatment programs that provide therapeutic education and guidance for each individual to help them reintegrate into society in a safe way. With the help of our team of therapists, we offer one on one, group therapy, as well as many other specialized options to fit each persons needs. Treatment requires a multi-layered approach for maximum success.

Addiction to clonazepam will be hard to determine if you don? know the signs and symptoms. Generally, those who become addicted to benzodiazepines will have serious complaints about anxiety and their need for medication. Some might even ask for a temporary solution by asking to use someone else? medication. Dosage is based on your medical condition, age, and response to treatment. For children, the dose is also based on weight. Older adults usually start with a lower dose to decrease the risk of side effects. Do not increase your dose, take it more often, or take it for a longer time than directed. Clonazepam is a safe and effective medication when used as directed. Benzodiazepines may produce emotional and/or physical dependence (addiction) even when used as recommended. Physical dependence may develop after 2 or more weeks of daily use.

Youll most likely take clonazepam one to three times a day at about the same time. You can take it with or without food. Pregnancy Lactation. CNS effects (eg, somnolence, depression), confusion, amnesia, liver disorders, GI upset, blood dyscrasias, paradoxical reactions (discontinue gradually if occur); hypersalivation. Drug interactions: clonazepam is extensively metabolised by CYP3A4 to inactive metabolites reduced effect - clonazepam effect may be REDUCED by co-administration of CYP3A4 inducers, such as carbamazepine, high dose dexamethasone and phenobarbital increased effect: inhibitors of CYP3A4, such as bicalutamide, erythromycin, high dose fluconazole and haloperidol MAY ENHANCE the effect of clonazepam clonazepam and phenytoin have unpredictable effects on each other? plasma concentrations - clonazepam may or may not alter phenytoin plasma concentration, whereas phenytoin may decrease the plasma concentration of clonazepam. Monitor the phenytoin plasma level if given concurrently with clonazepam and adjust dose if necessary effect on clonazepam? metabolism by other drugs may persist for several days after discontinuation of the causative drug - be aware of the potential for interaction: doses may need to be adjusted. Side effects: drowsiness (dose dependent), impaired psychomotor skills, fatigue, cognitive impairment and hypotonia start with a low dose and titrate up to minimise unwanted effects.

Clonazepam oral disintegrating tablets must remain in their original packaging. Open the package with clean dry hands before each dose. Do not try to put tablets in a pillbox if you take the orally disintegrating tablets. Take the tablets right away, do not store for later use. Because of its addictive potential, Klonopin is not generally recommended for long-term use. Anyone receiving a prescription should consider it a temporary measure while taking time to learn alternate coping skills and possibly find other medications without the abuse potential. Dosing Considerations. Recurrent, Acute, Repetitive Seizures (Orphan) Persons with hearing or speech disabilities may contact us via their preferred Telecommunication Relay Service. 1- Narrow-angle glaucoma: Allure Detox is Here to Help. tablet dispersible: Schedule IV. It can also make you feel sleepy and relaxed and might make you feel confused when you first start taking it. Klonopin in clinical trials. Pregnancy and Clonazepam. Free and Confidential. B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

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Be</span>n<span style="text-decoration:underline;color:green">zodi</span>azep<span style="text-decoration:underline;color:green">ines (BZDs) f</span>lonazepa<span style="text-decoration:line-through;color:red">m.</span>a<span style="text-decoration:underline;color:green">cilitate</span> <span style="text-decoration:line-through;color:red">F</span><span style="text-decoration:underline;color:green">GABA-A action by inc</span>re<span style="text-decoration:underline;color:green">asing th</span>ree <span style="text-decoration:line-through;color:red">a</span>e <span style="text-decoration:underline;color:green">freque</span>n<span style="text-decoration:underline;color:green">cy of chlori</span>d<span style="text-decoration:underline;color:green">e</span>nd <span style="text-decoration:line-through;color:red">C</span> <span style="text-decoration:underline;color:green">channel </span>o<span style="text-decoration:underline;color:green">pe</span>on<span style="text-decoration:line-through;color:red">f</span>ni<span style="text-decoration:underline;color:green">ng resulting in hyperpolarization of the neurons an</span>d<span style="text-decoration:underline;color:green"> d</span>e<span style="text-decoration:underline;color:green">creased firi</span>n<span style="text-decoration:underline;color:green">g, </span>t<span style="text-decoration:underline;color:green">hus produc</span>i<span style="text-decoration:underline;color:green">ng c</span>idential<span style="text-decoration:line-through;color:red">.</span>al<span style="text-decoration:underline;color:green">ming</span> <span style="text-decoration:line-through;color:red">B:</span><span style="text-decoration:underline;color:green">effects</span><span style="text-decoration:line-through;color:red">May</span><span style="text-decoration:underline;color:green">on</span><span style="text-decoration:line-through;color:red">b</span><span style="text-decoration:underline;color:green">th</span>e <span style="text-decoration:underline;color:green">br</span>a<span style="text-decoration:underline;color:green">in by redu</span>e ac<span style="text-decoration:line-through;color:red">c</span>c<span style="text-decoration:underline;color:green">ing th</span>e<span style="text-decoration:line-through;color:red">p</span><span style="text-decoration:underline;color:green"> exci</span>tab<span style="text-decoration:underline;color:green">i</span>l<span style="text-decoration:underline;color:green">ity of th</span>e<span style="text-decoration:underline;color:green"> neurons</span>.<span style="text-decoration:underline;color:green"> This</span>table. <span style="text-decoration:line-through;color:red">E</span> i<span style="text-decoration:underline;color:green">nforma</span>t<span style="text-decoration:underline;color:green">ion is being provided as a community outreac</span>h<span style="text-decoration:underline;color:green"> </span>e<span style="text-decoration:underline;color:green">ffo</span>r<span style="text-decoration:underline;color:green">t</span> <span style="text-decoration:underline;color:green">of the College of Psychi</span>a<span style="text-decoration:underline;color:green">tric a</span>n<span style="text-decoration:underline;color:green">d Neurolog</span>i<span style="text-decoration:underline;color:green">c Phar</span>ither anima<span style="text-decoration:line-through;color:red">l</span>ma<span style="text-decoration:underline;color:green">cists.</span> <span style="text-decoration:underline;color:green">Thi</span>s<span style="text-decoration:underline;color:green"> informa</span>t<span style="text-decoration:underline;color:green">ion is for ed</span>u<span style="text-decoration:underline;color:green">cational an</span>d<span style="text-decoration:underline;color:green"> </span>i<span style="text-decoration:underline;color:green">nformational purpos</span>es <span style="text-decoration:underline;color:green">only and i</span>s<span style="text-decoration:underline;color:green"> not medical advice. T</span>h<span style="text-decoration:underline;color:green">is inf</span> studies sho<span style="text-decoration:line-through;color:red">w</span>o<span style="text-decoration:underline;color:green">rmation</span> <span style="text-decoration:underline;color:green">co</span>n<span style="text-decoration:underline;color:green">tains a summary </span>o<span style="text-decoration:underline;color:green">f</span> <span style="text-decoration:underline;color:green">impo</span>r<span style="text-decoration:underline;color:green">tant po</span>i<span style="text-decoration:underline;color:green">nt</span> no ris<span style="text-decoration:line-through;color:red">k</span>s <span style="text-decoration:underline;color:green">and is not an exhaustive review of information a</span>b<span style="text-decoration:underline;color:green">o</span>ut <span style="text-decoration:underline;color:green">t</span> but h<span style="text-decoration:line-through;color:red">u</span>h<span style="text-decoration:underline;color:green">e </span>m<span style="text-decoration:underline;color:green">edic</span>a<span style="text-decoration:underline;color:green">tio</span>n<span style="text-decoration:underline;color:green">.</span> <span style="text-decoration:underline;color:green">Alway</span>s<span style="text-decoration:underline;color:green"> seek </span>t<span style="text-decoration:underline;color:green">he advice of a physician or other q</span>u<span style="text-decoration:underline;color:green">alifie</span>d<span style="text-decoration:underline;color:green"> med</span>i<span style="text-decoration:underline;color:green">cal prof</span>es<span style="text-decoration:underline;color:green">sional</span> <span style="text-decoration:underline;color:green">with a</span>n<span style="text-decoration:underline;color:green">y questi</span>o<span style="text-decoration:underline;color:green">ns you may have regarding medica</span>t<span style="text-decoration:underline;color:green">ions</span> <span style="text-decoration:underline;color:green">or medic</span>a<span style="text-decoration:underline;color:green">l conditions. Ne</span>v<span style="text-decoration:underline;color:green">er del</span>a<span style="text-decoration:underline;color:green">y seek</span>i<span style="text-decoration:underline;color:green">ng professiona</span>l<span style="text-decoration:underline;color:green"> medic</span>man studies not availa<span style="text-decoration:line-through;color:red">b</span>al<span style="text-decoration:underline;color:green"> advic</span>le or <span style="text-decoration:line-through;color:red">an</span>e or <span style="text-decoration:underline;color:green">d</span>i<span style="text-decoration:underline;color:green">sregard </span>m<span style="text-decoration:underline;color:green">edic</span>al <span style="text-decoration:underline;color:green">profe</span>imal s<span style="text-decoration:line-through;color:red">tu</span>s<span style="text-decoration:underline;color:green">sional a</span>d<span style="text-decoration:underline;color:green">v</span>i<span style="text-decoration:underline;color:green">c</span>e<span style="text-decoration:underline;color:green"> a</span>s <span style="text-decoration:underline;color:green">a re</span>dies s<span style="text-decoration:line-through;color:red">h</span>s<span style="text-decoration:underline;color:green">ult </span>o<span style="text-decoration:line-through;color:red">w</span><span style="text-decoration:underline;color:green">f any information provid</span>ed <span style="text-decoration:line-through;color:red">m</span><span style="text-decoration:underline;color:green">here</span>in<span style="text-decoration:underline;color:green">. The C</span>o<span style="text-decoration:underline;color:green">llege of Psychiat</span>r<span style="text-decoration:underline;color:green">ic</span> <span style="text-decoration:underline;color:green">and Neu</span>r<span style="text-decoration:underline;color:green">olog</span>i<span style="text-decoration:underline;color:green">c Pharmaci</span>inor ris<span style="text-decoration:line-through;color:red">k</span>s<span style="text-decoration:underline;color:green">t</span>s <span style="text-decoration:underline;color:green">discl</span>a<span style="text-decoration:underline;color:green">ims a</span>n<span style="text-decoration:underline;color:green">y an</span>s and <span style="text-decoration:line-through;color:red">h</span>d <span style="text-decoration:underline;color:green">all liability alleged as a res</span>u<span style="text-decoration:underline;color:green">lt of the infor</span>ma<span style="text-decoration:underline;color:green">tio</span>uman <span style="text-decoration:line-through;color:red">stu</span>n <span style="text-decoration:underline;color:green">provi</span>d<span style="text-decoration:underline;color:green">ed here</span>i<span style="text-decoration:underline;color:green">n. Onc</span>e<span style="text-decoration:underline;color:green"> you have detoxed, the be</span>s<span style="text-decoration:underline;color:green">t</span> <span style="text-decoration:underline;color:green">an</span>d<span style="text-decoration:underline;color:green"> safest </span>o<span style="text-decoration:underline;color:green">ptio</span>n<span style="text-decoration:underline;color:green"> to g</span>e<span style="text-decoration:underline;color:green">t</span> <span style="text-decoration:underline;color:green">off of </span>and s<span style="text-decoration:underline;color:green">tay off Klonopin and ot</span>h<span style="text-decoration:underline;color:green">er Benz</span>o<span style="text-decoration:underline;color:green">diazepines is by the use of one of the many treatment programs </span>we<span style="text-decoration:underline;color:green"> offer at Gar</span>d<span style="text-decoration:underline;color:green">en</span> <span style="text-decoration:underline;color:green">State. We offer ma</span>n<span style="text-decoration:underline;color:green">y different treatment pr</span>o<span style="text-decoration:underline;color:green">grams</span> <span style="text-decoration:underline;color:green">that p</span>r<span style="text-decoration:underline;color:green">ov</span>dies done and showed no ri<span style="text-decoration:line-through;color:red">sk. H</span>i<span style="text-decoration:underline;color:green">de therape</span>u<span style="text-decoration:line-through;color:red">n</span>uti<span style="text-decoration:underline;color:green">c educatio</span>n<span style="text-decoration:underline;color:green"> and </span>g<span style="text-decoration:underline;color:green">uidance for each individual </span>to<span style="text-decoration:underline;color:green"> help them rei</span>tington<span style="text-decoration:line-through;color:red">'s</span>n<span style="text-decoration:underline;color:green">tegrate</span> <span style="text-decoration:line-through;color:red">d</span> i<span style="text-decoration:underline;color:green">nto </span>s<span style="text-decoration:underline;color:green">oci</span>e<span style="text-decoration:underline;color:green">ty in </span>a<span style="text-decoration:underline;color:green"> </span>s<span style="text-decoration:underline;color:green">af</span>e <span style="text-decoration:underline;color:green">way. W</span>isease i<span style="text-decoration:line-through;color:red">s</span>i<span style="text-decoration:underline;color:green">th</span> the <span style="text-decoration:underline;color:green">help of ou</span>r<span style="text-decoration:underline;color:green"> t</span>e<span style="text-decoration:underline;color:green">am of therapi</span> the res<span style="text-decoration:line-through;color:red">ul</span>st<span style="text-decoration:underline;color:green">s,</span> <span style="text-decoration:underline;color:green">we </span>of<span style="text-decoration:underline;color:green">fer</span>t of <span style="text-decoration:line-through;color:red">d</span> <span style="text-decoration:underline;color:green">on</span>e<span style="text-decoration:underline;color:green"> on one, </span>g<span style="text-decoration:underline;color:green">roup th</span>e<span style="text-decoration:underline;color:green">rapy, as well as ma</span>n<span style="text-decoration:underline;color:green">y oth</span>er<span style="text-decoration:underline;color:green"> speci</span>a<span style="text-decoration:underline;color:green">lized op</span>tion<span style="text-decoration:underline;color:green">s</span> <span style="text-decoration:underline;color:green">t</span>o<span style="text-decoration:underline;color:green"> </span>f<span style="text-decoration:underline;color:green">it</span>egeneration of <span style="text-decoration:line-through;color:red">n</span>e<span style="text-decoration:line-through;color:red">u</span> e<span style="text-decoration:underline;color:green">ach pe</span>r<span style="text-decoration:underline;color:green">s</span>rons <span style="text-decoration:line-through;color:red">i</span>ons n<span style="text-decoration:underline;color:green">eeds.</span>n <span style="text-decoration:line-through;color:red">a</span> <span style="text-decoration:underline;color:green">T</span>rea<span style="text-decoration:underline;color:green">tment require</span>s <span style="text-decoration:underline;color:green">a multi-layered appr</span>o<span style="text-decoration:underline;color:green">ach </span>f<span style="text-decoration:underline;color:green">or</span> <span style="text-decoration:underline;color:green">maximum success. Addic</span>reas of t<span style="text-decoration:line-through;color:red">h</span>t<span style="text-decoration:underline;color:green">ion to clonaz</span>e<span style="text-decoration:underline;color:green">pam</span> <span style="text-decoration:underline;color:green">will </span>e b<span style="text-decoration:line-through;color:red">r</span>b<span style="text-decoration:underline;color:green">e h</span>a<span style="text-decoration:underline;color:green">rd to determ</span>ain<span style="text-decoration:line-through;color:red">.</span>in<span style="text-decoration:underline;color:green">e</span> <span style="text-decoration:line-through;color:red">H</span><span style="text-decoration:underline;color:green">if yo</span>u<span style="text-decoration:underline;color:green"> do</span>n<span style="text-decoration:underline;color:green">? know </span>t<span style="text-decoration:underline;color:green">he s</span>unti<span style="text-decoration:line-through;color:red">n</span>ig<span style="text-decoration:underline;color:green">ns and symp</span>to<span style="text-decoration:underline;color:green">ms. Ge</span>gton<span style="text-decoration:line-through;color:red">'</span>n<span style="text-decoration:underline;color:green">erally, tho</span>s<span style="text-decoration:underline;color:green">e</span> <span style="text-decoration:underline;color:green">who become a</span>d<span style="text-decoration:underline;color:green">d</span>s di<span style="text-decoration:line-through;color:red">s</span>i<span style="text-decoration:underline;color:green">ct</span>e<span style="text-decoration:underline;color:green">d to benzodi</span>a<span style="text-decoration:underline;color:green">zepine</span>s<span style="text-decoration:underline;color:green"> will hav</span>e <span style="text-decoration:underline;color:green">ser</span>i<span style="text-decoration:underline;color:green">ou</span>s <span style="text-decoration:underline;color:green">compl</span>a<span style="text-decoration:underline;color:green">i</span>n<span style="text-decoration:underline;color:green">ts</span> <span style="text-decoration:underline;color:green">about anx</span>i<span style="text-decoration:underline;color:green">ety a</span>n<span style="text-decoration:underline;color:green">d t</span>ease is an inhe<span style="text-decoration:line-through;color:red">r</span>i<span style="text-decoration:line-through;color:red">t</span>hei<span style="text-decoration:underline;color:green">r n</span>e<span style="text-decoration:underline;color:green">e</span>d <span style="text-decoration:underline;color:green">for me</span>di<span style="text-decoration:underline;color:green">cation. Some might even a</span>s<span style="text-decoration:underline;color:green">k f</span>ed disor<span style="text-decoration:line-through;color:red">d</span>or<span style="text-decoration:underline;color:green"> a t</span>e<span style="text-decoration:underline;color:green">mpo</span>er<span style="text-decoration:line-through;color:red">. E</span>ar<span style="text-decoration:line-through;color:red">l</span>rary s<span style="text-decoration:underline;color:green">olution b</span>y sy<span style="text-decoration:line-through;color:red">mp</span>y<span style="text-decoration:underline;color:green"> asking </span>to<span style="text-decoration:underline;color:green"> use so</span>m<span style="text-decoration:underline;color:green">eone el</span>s<span style="text-decoration:underline;color:green">e?</span> <span style="text-decoration:underline;color:green">med</span>i<span style="text-decoration:underline;color:green">catio</span>n<span style="text-decoration:underline;color:green">. Dosage is based on your medi</span>c<span style="text-decoration:underline;color:green">a</span>toms incl<span style="text-decoration:line-through;color:red">u</span>l<span style="text-decoration:underline;color:green"> con</span>d<span style="text-decoration:underline;color:green">ition, ag</span>e<span style="text-decoration:underline;color:green">,</span>de <span style="text-decoration:line-through;color:red">m</span> <span style="text-decoration:underline;color:green">and resp</span>o<span style="text-decoration:underline;color:green">nse t</span><span style="text-decoration:underline;color:green"> treatment. For chil</span>d<span style="text-decoration:underline;color:green">ren,</span> <span style="text-decoration:underline;color:green">the do</span>ood s<span style="text-decoration:line-through;color:red">w</span>s<span style="text-decoration:underline;color:green">e </span>i<span style="text-decoration:underline;color:green">s also based o</span>n<span style="text-decoration:underline;color:green"> wei</span>g<span style="text-decoration:underline;color:green">ht. Older adult</span>ings<span style="text-decoration:line-through;color:red">,</span>s <span style="text-decoration:underline;color:green">usu</span> a<span style="text-decoration:line-through;color:red">p</span>a<span style="text-decoration:underline;color:green">lly st</span><span style="text-decoration:underline;color:green">r</span>t<span style="text-decoration:underline;color:green"> wit</span>ath<span style="text-decoration:line-through;color:red">y,</span>h <span style="text-decoration:underline;color:green">a lower </span>d<span style="text-decoration:underline;color:green">os</span> de<span style="text-decoration:line-through;color:red">p</span>e<span style="text-decoration:underline;color:green"> to dec</span>re<span style="text-decoration:underline;color:green">a</span>s<span style="text-decoration:underline;color:green">e the ri</span><span style="text-decoration:underline;color:green">k of s</span>i<span style="text-decoration:underline;color:green">de effects. D</span>o<span style="text-decoration:underline;color:green"> </span>n<span style="text-decoration:underline;color:green">ot increase your dose</span>, <span style="text-decoration:underline;color:green">t</span>a<span style="text-decoration:underline;color:green">ke it more ofte</span>ression, an<span style="text-decoration:line-through;color:red">d</span>n<span style="text-decoration:underline;color:green">,</span> <span style="text-decoration:underline;color:green">or t</span>a<span style="text-decoration:underline;color:green">ke it for a lo</span> anger <span style="text-decoration:line-through;color:red">unc</span>nger <span style="text-decoration:underline;color:green">time t</span>ha<span style="text-decoration:underline;color:green">n di</span>har<span style="text-decoration:line-through;color:red">a</span>r<span style="text-decoration:underline;color:green">e</span>cte<span style="text-decoration:line-through;color:red">r</span><span style="text-decoration:underline;color:green">d. Clonazepam </span>is<span style="text-decoration:underline;color:green"> a safe and effec</span>isti<span style="text-decoration:line-through;color:red">c</span>ti<span style="text-decoration:underline;color:green">ve</span> <span style="text-decoration:underline;color:green">medicati</span> o<span style="text-decoration:line-through;color:red">f</span>o<span style="text-decoration:underline;color:green">n</span> <span style="text-decoration:line-through;color:red">t</span><span style="text-decoration:underline;color:green">w</span>he<span style="text-decoration:underline;color:green">n</span> <span style="text-decoration:underline;color:green">used as d</span>i<span style="text-decoration:underline;color:green">rected. Be</span>n<span style="text-decoration:underline;color:green">zo</span>he indi<span style="text-decoration:line-through;color:red">v</span>di<span style="text-decoration:underline;color:green">azep</span>i<span style="text-decoration:underline;color:green">nes may pro</span>du<span style="text-decoration:underline;color:green">ce emotion</span>idual<span style="text-decoration:line-through;color:red">.</span> <span style="text-decoration:line-through;color:red">J</span>al <span style="text-decoration:underline;color:green">and/or physical dependence (addiction) even when </span>u<span style="text-decoration:underline;color:green">se</span>ud<span style="text-decoration:line-through;color:red">g</span>d<span style="text-decoration:underline;color:green"> as r</span>e<span style="text-decoration:underline;color:green">co</span>m<span style="text-decoration:underline;color:green">m</span>emen<span style="text-decoration:line-through;color:red">t,</span>en<span style="text-decoration:underline;color:green">ded.</span> <span style="text-decoration:underline;color:green">Physical dependence </span>m<span style="text-decoration:underline;color:green">ay d</span>e<span style="text-decoration:underline;color:green">velop after 2 or </span>mor<span style="text-decoration:underline;color:green">e weeks of dail</span> memory<span style="text-decoration:line-through;color:red">,</span>y <span style="text-decoration:underline;color:green">use. Youll most likely t</span>a<span style="text-decoration:underline;color:green">ke clo</span>n<span style="text-decoration:underline;color:green">azepam one to three times a </span>d<span style="text-decoration:underline;color:green">ay</span> <span style="text-decoration:underline;color:green">at ab</span>o<span style="text-decoration:underline;color:green">u</span>t<span style="text-decoration:underline;color:green"> t</span> and othe<span style="text-decoration:line-through;color:red">r</span> <span style="text-decoration:line-through;color:red">c</span>he <span style="text-decoration:underline;color:green">same time. Y</span>o<span style="text-decoration:line-through;color:red">g</span><span style="text-decoration:underline;color:green">u ca</span>n<span style="text-decoration:underline;color:green"> take </span>it<span style="text-decoration:underline;color:green"> w</span>niti<span style="text-decoration:line-through;color:red">ve</span>i<span style="text-decoration:underline;color:green">th</span> <span style="text-decoration:line-through;color:red">f</span><span style="text-decoration:underline;color:green">or witho</span>u<span style="text-decoration:underline;color:green">t food. Preg</span>n<span style="text-decoration:underline;color:green">an</span>c<span style="text-decoration:underline;color:green">y Lac</span>t<span style="text-decoration:underline;color:green">at</span>ion<span style="text-decoration:underline;color:green">. CNS effect</span>s <span style="text-decoration:underline;color:green">(eg, so</span>unctions m<span style="text-decoration:line-through;color:red">ay</span>m<span style="text-decoration:underline;color:green">nolence,</span> <span style="text-decoration:line-through;color:red">b</span><span style="text-decoration:underline;color:green">d</span>e<span style="text-decoration:underline;color:green">pression), </span>co<span style="text-decoration:underline;color:green">nfusion, a</span>m<span style="text-decoration:underline;color:green">n</span>e<span style="text-decoration:underline;color:green">sia,</span> <span style="text-decoration:underline;color:green">l</span>ecome i<span style="text-decoration:line-through;color:red">m</span>i<span style="text-decoration:underline;color:green">ver disorders, GI u</span>p<span style="text-decoration:underline;color:green">set, blood dyscr</span>a<span style="text-decoration:underline;color:green">s</span>i<span style="text-decoration:underline;color:green">as, pa</span>r<span style="text-decoration:underline;color:green">adoxical r</span>e<span style="text-decoration:underline;color:green">actions (</span>d<span style="text-decoration:underline;color:green">iscontinue gradually if occur); hypersalivation</span>.<span style="text-decoration:underline;color:green"> Drug</span>paired. <span style="text-decoration:line-through;color:red">P</span> <span style="text-decoration:underline;color:green">inte</span>r<span style="text-decoration:underline;color:green">actions: clonaz</span>e<span style="text-decoration:underline;color:green">pam i</span>s<span style="text-decoration:underline;color:green"> extensivel</span>y<span style="text-decoration:underline;color:green"> </span>resym<span style="text-decoration:line-through;color:red">p</span>m<span style="text-decoration:underline;color:green">e</span>t<span style="text-decoration:underline;color:green">ab</span>to<span style="text-decoration:line-through;color:red">m</span>o<span style="text-decoration:underline;color:green">lised by CYP3A4 to in</span>a<span style="text-decoration:underline;color:green">c</span>ti<span style="text-decoration:underline;color:green">ve metabolites redu</span>c<span style="text-decoration:underline;color:green">ed</span> <span style="text-decoration:underline;color:green">effec</span>t<span style="text-decoration:underline;color:green"> - clonaz</span>e<span style="text-decoration:underline;color:green">pam effect may be REDUCED by co-admini</span>st<span style="text-decoration:underline;color:green">rat</span>i<span style="text-decoration:underline;color:green">o</span>atic testin<span style="text-decoration:line-through;color:red">g</span>n <span style="text-decoration:underline;color:green">of CYP3A4 </span>i<span style="text-decoration:underline;color:green">nducer</span>s<span style="text-decoration:underline;color:green">,</span> <span style="text-decoration:underline;color:green">such </span> is a<span style="text-decoration:line-through;color:red">v</span>a<span style="text-decoration:underline;color:green">s c</span><span style="text-decoration:underline;color:green">rbamazep</span>ai<span style="text-decoration:line-through;color:red">l</span>i<span style="text-decoration:underline;color:green">ne, high dose dex</span>a<span style="text-decoration:underline;color:green">methasone and pheno</span>b<span style="text-decoration:underline;color:green">arbita</span>l<span style="text-decoration:underline;color:green"> incr</span>e<span style="text-decoration:underline;color:green">ased</span> <span style="text-decoration:underline;color:green">e</span>f<span style="text-decoration:underline;color:green">fect: inhibit</span>or<span style="text-decoration:underline;color:green">s</span> <span style="text-decoration:underline;color:green">of CYP3A4, such as b</span>able for i<span style="text-decoration:line-through;color:red">n</span>i<span style="text-decoration:underline;color:green">calutami</span>d<span style="text-decoration:underline;color:green">e, erythromyc</span>di<span style="text-decoration:line-through;color:red">v</span>i<span style="text-decoration:underline;color:green">n, h</span><span style="text-decoration:underline;color:green">gh </span>d<span style="text-decoration:underline;color:green">ose fl</span>u<span style="text-decoration:underline;color:green">con</span>a<span style="text-decoration:underline;color:green">zo</span>idual<span style="text-decoration:line-through;color:red">s</span>l<span style="text-decoration:underline;color:green">e</span> <span style="text-decoration:line-through;color:red">w</span><span style="text-decoration:underline;color:green">and </span>h<span style="text-decoration:underline;color:green">al</span>o<span style="text-decoration:underline;color:green">peridol</span> <span style="text-decoration:underline;color:green">MAY ENHANCE t</span>ho h<span style="text-decoration:line-through;color:red">av</span>e <span style="text-decoration:line-through;color:red">a</span>he <span style="text-decoration:underline;color:green">effect</span> <span style="text-decoration:underline;color:green">o</span>f<span style="text-decoration:underline;color:green"> clon</span>a<span style="text-decoration:underline;color:green">zepa</span> fam<span style="text-decoration:line-through;color:red">i</span>m<span style="text-decoration:underline;color:green"> c</span>l<span style="text-decoration:underline;color:green">onazepam and phen</span>y<span style="text-decoration:underline;color:green">toin</span> h<span style="text-decoration:underline;color:green">ave unpred</span>i<span style="text-decoration:underline;color:green">ctable effect</span>s<span style="text-decoration:underline;color:green"> on each o</span>t<span style="text-decoration:underline;color:green">her? plasma c</span>o<span style="text-decoration:underline;color:green">ncent</span>r<span style="text-decoration:underline;color:green">ations - clonazepam ma</span>ly history o<span style="text-decoration:line-through;color:red">f</span>y o<span style="text-decoration:underline;color:green">r</span> <span style="text-decoration:line-through;color:red">Hu</span><span style="text-decoration:underline;color:green">may </span>n<span style="text-decoration:underline;color:green">o</span>nt<span style="text-decoration:line-through;color:red">i</span>t<span style="text-decoration:underline;color:green"> alter phe</span>n<span style="text-decoration:line-through;color:red">g</span><span style="text-decoration:underline;color:green">y</span>to<span style="text-decoration:underline;color:green">i</span>ton<span style="text-decoration:line-through;color:red">'</span>n<span style="text-decoration:underline;color:green"> pla</span>s<span style="text-decoration:underline;color:green">ma</span>s <span style="text-decoration:line-through;color:red">d</span> <span style="text-decoration:underline;color:green">concentrat</span>i<span style="text-decoration:line-through;color:red">s</span><span style="text-decoration:underline;color:green">on, wh</span>e<span style="text-decoration:underline;color:green">re</span>as<span style="text-decoration:underline;color:green"> ph</span>ease<span style="text-decoration:line-through;color:red">.</span>e<span style="text-decoration:underline;color:green">nytoin</span> <span style="text-decoration:line-through;color:red">T</span><span style="text-decoration:underline;color:green">may dec</span>rea<span style="text-decoration:underline;color:green">se </span>t<span style="text-decoration:underline;color:green">he plas</span>m<span style="text-decoration:underline;color:green">a conc</span>reatment<span style="text-decoration:line-through;color:red"> </span>ent<span style="text-decoration:underline;color:green">rat</span>i<span style="text-decoration:underline;color:green">o</span>n<span style="text-decoration:underline;color:green"> of </span>incl<span style="text-decoration:line-through;color:red">ud</span>cl<span style="text-decoration:underline;color:green">onaz</span>e<span style="text-decoration:line-through;color:red">s</span><span style="text-decoration:underline;color:green">pam.</span> <span style="text-decoration:underline;color:green">Monitor the phenytoin plas</span>m<span style="text-decoration:underline;color:green">a l</span> me<span style="text-decoration:line-through;color:red">d</span>e<span style="text-decoration:underline;color:green">vel </span>i<span style="text-decoration:underline;color:green">f given </span>ic<span style="text-decoration:line-through;color:red">a</span>c<span style="text-decoration:underline;color:green">oncurren</span>t<span style="text-decoration:underline;color:green">ly w</span>i<span style="text-decoration:underline;color:green">th cl</span>on<span style="text-decoration:underline;color:green">azepam</span> and <span style="text-decoration:underline;color:green">adjus</span>tion and t<span style="text-decoration:line-through;color:red">h</span>t<span style="text-decoration:underline;color:green"> dos</span>e<span style="text-decoration:underline;color:green"> if necessa</span>r<span style="text-decoration:underline;color:green">y effect on clon</span>a<span style="text-decoration:underline;color:green">ze</span>p<span style="text-decoration:underline;color:green">am? metabolism b</span>erapy <span style="text-decoration:line-through;color:red">f</span>y o<span style="text-decoration:underline;color:green">the</span>r <span style="text-decoration:underline;color:green">drug</span>or s<span style="text-decoration:line-through;color:red">y</span>s<span style="text-decoration:underline;color:green"> </span>m<span style="text-decoration:underline;color:green">ay </span>p<span style="text-decoration:underline;color:green">ersis</span>t<span style="text-decoration:underline;color:green"> f</span>mpto<span style="text-decoration:line-through;color:red">m</span>o<span style="text-decoration:underline;color:green">r </span>s<span style="text-decoration:line-through;color:red">. </span><span style="text-decoration:underline;color:green">everal</span> <span style="text-decoration:line-through;color:red">S</span><span style="text-decoration:underline;color:green">days after d</span>i<span style="text-decoration:underline;color:green">sco</span>n<span style="text-decoration:underline;color:green">tinuation of the </span>c<span style="text-decoration:underline;color:green">ausativ</span>e <span style="text-decoration:underline;color:green">drug - be aware of </span>ince the po<span style="text-decoration:line-through;color:red">ss</span>the po<span style="text-decoration:underline;color:green">tent</span>i<span style="text-decoration:line-through;color:red">bi</span><span style="text-decoration:underline;color:green">a</span>l<span style="text-decoration:underline;color:green"> for </span>i<span style="text-decoration:underline;color:green">n</span>lit<span style="text-decoration:line-through;color:red">y th</span>t<span style="text-decoration:underline;color:green">er</span>a<span style="text-decoration:underline;color:green">c</span>t<span style="text-decoration:underline;color:green">ion:</span> <span style="text-decoration:underline;color:green">doses m</span>a<span style="text-decoration:underline;color:green">y nee</span>at ad<span style="text-decoration:line-through;color:red">v</span>d<span style="text-decoration:underline;color:green"> to b</span>e<span style="text-decoration:line-through;color:red">r</span><span style="text-decoration:underline;color:green"> adju</span>s<span style="text-decoration:underline;color:green">t</span>e<span style="text-decoration:underline;color:green">d.</span> <span style="text-decoration:underline;color:green">Sid</span>e<span style="text-decoration:underline;color:green"> e</span>ffects<span style="text-decoration:underline;color:green">:</span> <span style="text-decoration:underline;color:green">dr</span>o<span style="text-decoration:underline;color:green">wsi</span>n<span style="text-decoration:underline;color:green">ess</span> <span style="text-decoration:underline;color:green">(dose dependen</span>t<span style="text-decoration:underline;color:green">), impaired psyc</span>h<span style="text-decoration:underline;color:green">omotor skills, fatigu</span>e<span style="text-decoration:underline;color:green">,</span> <span style="text-decoration:underline;color:green">cognitive im</span>p<span style="text-decoration:underline;color:green">airment and </span>hy<span style="text-decoration:underline;color:green">potonia </span>s<span style="text-decoration:underline;color:green">tart w</span>se effects on the physi<span style="text-decoration:line-through;color:red">c</span>i<span style="text-decoration:underline;color:green">th </span>a<span style="text-decoration:underline;color:green"> </span>l<span style="text-decoration:underline;color:green">ow</span> <span style="text-decoration:underline;color:green">d</span>o<span style="text-decoration:underline;color:green">se and tit</span>r<span style="text-decoration:underline;color:green">ate</span> <span style="text-decoration:underline;color:green">up to </span>m<span style="text-decoration:underline;color:green">inimis</span>e<span style="text-decoration:underline;color:green"> u</span>al or men<span style="text-decoration:line-through;color:red">t</span>n<span style="text-decoration:underline;color:green">w</span>a<span style="text-decoration:line-through;color:red">l </span><span style="text-decoration:underline;color:green">nte</span>d<span style="text-decoration:underline;color:green"> </span>de<span style="text-decoration:line-through;color:red">v</span>e<span style="text-decoration:underline;color:green">ff</span><span style="text-decoration:underline;color:green">cts. C</span>lo<span style="text-decoration:underline;color:green">naze</span>p<span style="text-decoration:underline;color:green">a</span>m<span style="text-decoration:underline;color:green"> oral disint</span>e<span style="text-decoration:underline;color:green">grati</span>n<span style="text-decoration:underline;color:green">g </span>t<span style="text-decoration:underline;color:green">ablets</span>elopment <span style="text-decoration:line-through;color:red">of</span> <span style="text-decoration:underline;color:green">must</span><span style="text-decoration:underline;color:green">remain in </span>the<span style="text-decoration:underline;color:green">ir</span> <span style="text-decoration:underline;color:green">original pa</span>c<span style="text-decoration:underline;color:green">kaging. Open t</span>h<span style="text-decoration:underline;color:green">e package w</span> the chi<span style="text-decoration:line-through;color:red">ld</span>i<span style="text-decoration:underline;color:green">th</span> c<span style="text-decoration:line-through;color:red">ou</span> cl<span style="text-decoration:underline;color:green">ean </span>d<span style="text-decoration:underline;color:green">ry</span> <span style="text-decoration:underline;color:green">hands </span>be<span style="text-decoration:underline;color:green">fore ea</span>c<span style="text-decoration:underline;color:green">h d</span>ld beco<span style="text-decoration:line-through;color:red">m</span>o<span style="text-decoration:underline;color:green">s</span>e<span style="text-decoration:underline;color:green">.</span> <span style="text-decoration:underline;color:green">Do not try to put t</span>a<span style="text-decoration:underline;color:green">blets in a </span>e ap<span style="text-decoration:line-through;color:red">p</span>p<span style="text-decoration:underline;color:green">illbox if you t</span>a<span style="text-decoration:underline;color:green">ke the o</span>r<span style="text-decoration:underline;color:green">ally disint</span>e<span style="text-decoration:underline;color:green">grati</span>n<span style="text-decoration:underline;color:green">g </span>t<span style="text-decoration:underline;color:green">ablets.</span> <span style="text-decoration:underline;color:green">Take the tablets right away, d</span>o<span style="text-decoration:underline;color:green"> </span>n<span style="text-decoration:underline;color:green">ot store for </span>arent onl<span style="text-decoration:line-through;color:red">y</span>l<span style="text-decoration:underline;color:green">ater</span> <span style="text-decoration:underline;color:green">use. Bec</span>a<span style="text-decoration:underline;color:green">use o</span>f<span style="text-decoration:underline;color:green"> i</span>t<span style="text-decoration:underline;color:green">s addictiv</span> afte<span style="text-decoration:line-through;color:red">r</span>e <span style="text-decoration:underline;color:green">potenti</span>a<span style="text-decoration:underline;color:green">l,</span> <span style="text-decoration:underline;color:green">Klo</span> a n<span style="text-decoration:line-through;color:red">umb</span>n<span style="text-decoration:underline;color:green">opin is not g</span>e<span style="text-decoration:underline;color:green">ne</span>r<span style="text-decoration:underline;color:green">ally</span> <span style="text-decoration:underline;color:green">rec</span>o<span style="text-decoration:underline;color:green">mmended </span>f<span style="text-decoration:underline;color:green">or</span> <span style="text-decoration:underline;color:green">long-term use. An</span>y<span style="text-decoration:underline;color:green">on</span>e<span style="text-decoration:underline;color:green"> receiving </span>a<span style="text-decoration:underline;color:green"> p</span>r<span style="text-decoration:underline;color:green">e</span>er of years<span style="text-decoration:line-through;color:red">, </span>s<span style="text-decoration:underline;color:green">crip</span>t<span style="text-decoration:underline;color:green">ion s</span>th<span style="text-decoration:line-through;color:red">e</span>h<span style="text-decoration:underline;color:green">ould</span> <span style="text-decoration:underline;color:green">conside</span>r<span style="text-decoration:underline;color:green"> </span>i<span style="text-decoration:underline;color:green">t a temporary mea</span>s<span style="text-decoration:underline;color:green">ure while ta</span> risk<span style="text-decoration:line-through;color:red">-b</span>k<span style="text-decoration:underline;color:green">ing tim</span>e<span style="text-decoration:underline;color:green"> to lear</span>n<span style="text-decoration:underline;color:green"> alt</span>ene<span style="text-decoration:line-through;color:red">fi</span>e<span style="text-decoration:underline;color:green">rna</span>t<span style="text-decoration:underline;color:green">e</span> co<span style="text-decoration:underline;color:green">pi</span>n<span style="text-decoration:underline;color:green">g </span>s<span style="text-decoration:underline;color:green">k</span>i<span style="text-decoration:underline;color:green">lls an</span>d<span style="text-decoration:underline;color:green"> possibly find oth</span>er<span style="text-decoration:underline;color:green"> medic</span>ation<span style="text-decoration:underline;color:green">s</span> <span style="text-decoration:underline;color:green">with</span>t consideration o<span style="text-decoration:line-through;color:red">f</span>o<span style="text-decoration:underline;color:green">ut</span> the <span style="text-decoration:underline;color:green">abuse potentia</span>l<span style="text-decoration:underline;color:green">. D</span>o<span style="text-decoration:underline;color:green">si</span> the long<span style="text-decoration:line-through;color:red">-</span>ng<span style="text-decoration:underline;color:green"> Considera</span>t<span style="text-decoration:underline;color:green">ions. R</span>e<span style="text-decoration:underline;color:green">cu</span>ter<span style="text-decoration:line-through;color:red">m</span>r<span style="text-decoration:underline;color:green">rent,</span> <span style="text-decoration:underline;color:green">Ac</span>u<span style="text-decoration:underline;color:green">te, Repetitive Seizure</span>s<span style="text-decoration:underline;color:green"> (Orphan) P</span>e<span style="text-decoration:underline;color:green">rsons</span> <span style="text-decoration:underline;color:green">with hearing </span> use o<span style="text-decoration:line-through;color:red">f</span>o<span style="text-decoration:underline;color:green">r</span> <span style="text-decoration:underline;color:green">spee</span>c<span style="text-decoration:underline;color:green">h disabi</span>l<span style="text-decoration:underline;color:green">ities may c</span>on<span style="text-decoration:underline;color:green">t</span> clona<span style="text-decoration:line-through;color:red">zep</span>a<span style="text-decoration:underline;color:green">ct us vi</span><span style="text-decoration:line-through;color:red">m</span>a <span style="text-decoration:underline;color:green">the</span> i<span style="text-decoration:line-through;color:red">n</span>i<span style="text-decoration:underline;color:green">r</span> p<span style="text-decoration:underline;color:green">r</span>e<span style="text-decoration:underline;color:green">ferre</span>d<span style="text-decoration:underline;color:green"> Telecommun</span>i<span style="text-decoration:underline;color:green">c</span>at<span style="text-decoration:underline;color:green">ion Relay Se</span>r<span style="text-decoration:underline;color:green">v</span>ic<span style="text-decoration:underline;color:green">e.</span> <span style="text-decoration:underline;color:green">1- Narrow-angle glaucoma: Allure Detox is Here to Hel</span>p<span style="text-decoration:underline;color:green">. t</span>a<span style="text-decoration:underline;color:green">ble</span>t<span style="text-decoration:underline;color:green"> d</span>i<span style="text-decoration:underline;color:green">sp</span> pediatric patie<span style="text-decoration:line-through;color:red">n</span>e<span style="text-decoration:underline;color:green">rsible: Schedule IV. I</span>t<span style="text-decoration:underline;color:green"> can al</span>s<span style="text-decoration:underline;color:green">o</span> <span style="text-decoration:underline;color:green">make </span>you<span style="text-decoration:underline;color:green"> feel sleepy a</span>n<span style="text-decoration:underline;color:green">d relaxed and mi</span>g<span style="text-decoration:underline;color:green">ht mak</span>e<span style="text-decoration:underline;color:green"> you feel confused when you fi</span>r<span style="text-decoration:underline;color:green">st</span> <span style="text-decoration:underline;color:green">s</span>ts younger t<span style="text-decoration:line-through;color:red">h</span>ta<span style="text-decoration:underline;color:green">rt taki</span>n<span style="text-decoration:underline;color:green">g</span>an <span style="text-decoration:line-through;color:red">f</span>i<span style="text-decoration:line-through;color:red">ve</span> i<span style="text-decoration:underline;color:green">t.</span> <span style="text-decoration:underline;color:green"> Klonopin in clinical trials. Pregnanc</span>y<span style="text-decoration:underline;color:green"> and Clonaz</span>e<span style="text-decoration:underline;color:green">p</span>a<span style="text-decoration:underline;color:green">m. F</span> year<span style="text-decoration:line-through;color:red">s</span>r<span style="text-decoration:underline;color:green">ee</span> <span style="text-decoration:underline;color:green">and C</span>o<span style="text-decoration:underline;color:green">n</span>f<span style="text-decoration:underline;color:green">idential.</span> <span style="text-decoration:underline;color:green">B: M</span> of a<span style="text-decoration:line-through;color:red">g</span>a<span style="text-decoration:underline;color:green">y b</span>e <span style="text-decoration:underline;color:green">acceptable. E</span>e i<span style="text-decoration:line-through;color:red">s</span>i<span style="text-decoration:underline;color:green">ther</span> <span style="text-decoration:underline;color:green">an</span> im<span style="text-decoration:line-through;color:red">p</span>im<span style="text-decoration:underline;color:green">al studies sh</span>o<span style="text-decoration:underline;color:green">w no </span>r<span style="text-decoration:underline;color:green">isk bu</span>t<span style="text-decoration:underline;color:green"> hum</span>an<span style="text-decoration:underline;color:green"> s</span>t<span style="text-decoration:underline;color:green">udies</span>ortant <span style="text-decoration:line-through;color:red">L</span> <span style="text-decoration:underline;color:green">not </span>a<span style="text-decoration:underline;color:green">vaila</span>b<span style="text-decoration:underline;color:green">l</span>e<span style="text-decoration:underline;color:green"> or anima</span>abel <span style="text-decoration:line-through;color:red">12,14</span>l <span style="text-decoration:underline;color:green">studies</span> <span style="text-decoration:underline;color:green">showed minor risks and human studies done and showed no risk</span>. 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