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 Clonazepam is highly potent and a long-acting benzodiazepine. It exerts its pharmacological effects by acting as a positive allosteric modulator on GABA-A receptors. The GABA-A receptor is a ligand-gated chloride ion-selective channel whose endogenous ligand is GABA (gamma-aminobutyric acid). Benzodiazepines (BZDs) facilitate GABA-A action by increasing the frequency of chloride channel opening resulting in hyperpolarization of the neurons and decreased firing, thus producing calming effects on the brain by reducing the excitability of the neurons.

This information is being provided as a community outreach effort of the College of Psychiatric and Neurologic Pharmacists. This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication. Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions. Never delay seeking professional medical advice or disregard medical professional advice as a result of any information provided herein. The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability alleged as a result of the information provided herein. Once you have detoxed, the best and safest option to get off of and stay off Klonopin and other Benzodiazepines is by the use of one of the many treatment programs we offer at Garden State. We offer many different treatment programs that provide therapeutic education and guidance for each individual to help them reintegrate into society in a safe way. With the help of our team of therapists, we offer one on one, group therapy, as well as many other specialized options to fit each persons needs. Treatment requires a multi-layered approach for maximum success.

Addiction to clonazepam will be hard to determine if you don? know the signs and symptoms. Generally, those who become addicted to benzodiazepines will have serious complaints about anxiety and their need for medication. Some might even ask for a temporary solution by asking to use someone else? medication. Dosage is based on your medical condition, age, and response to treatment. For children, the dose is also based on weight. Older adults usually start with a lower dose to decrease the risk of side effects. Do not increase your dose, take it more often, or take it for a longer time than directed. Clonazepam is a safe and effective medication when used as directed. Benzodiazepines may produce emotional and/or physical dependence (addiction) even when used as recommended. Physical dependence may develop after 2 or more weeks of daily use.

Youll most likely take clonazepam one to three times a day at about the same time. You can take it with or without food. Pregnancy Lactation. CNS effects (eg, somnolence, depression), confusion, amnesia, liver disorders, GI upset, blood dyscrasias, paradoxical reactions (discontinue gradually if occur); hypersalivation. Drug interactions: clonazepam is extensively metabolised by CYP3A4 to inactive metabolites reduced effect - clonazepam effect may be REDUCED by co-administration of CYP3A4 inducers, such as carbamazepine, high dose dexamethasone and phenobarbital increased effect: inhibitors of CYP3A4, such as bicalutamide, erythromycin, high dose fluconazole and haloperidol MAY ENHANCE the effect of clonazepam clonazepam and phenytoin have unpredictable effects on each other? plasma concentrations - clonazepam may or may not alter phenytoin plasma concentration, whereas phenytoin may decrease the plasma concentration of clonazepam. Monitor the phenytoin plasma level if given concurrently with clonazepam and adjust dose if necessary effect on clonazepam? metabolism by other drugs may persist for several days after discontinuation of the causative drug - be aware of the potential for interaction: doses may need to be adjusted. Side effects: drowsiness (dose dependent), impaired psychomotor skills, fatigue, cognitive impairment and hypotonia start with a low dose and titrate up to minimise unwanted effects.

Clonazepam oral disintegrating tablets must remain in their original packaging. Open the package with clean dry hands before each dose. Do not try to put tablets in a pillbox if you take the orally disintegrating tablets. Take the tablets right away, do not store for later use. Because of its addictive potential, Klonopin is not generally recommended for long-term use. Anyone receiving a prescription should consider it a temporary measure while taking time to learn alternate coping skills and possibly find other medications without the abuse potential. Dosing Considerations. Recurrent, Acute, Repetitive Seizures (Orphan) Persons with hearing or speech disabilities may contact us via their preferred Telecommunication Relay Service. 1- Narrow-angle glaucoma: Allure Detox is Here to Help. tablet dispersible: Schedule IV. It can also make you feel sleepy and relaxed and might make you feel confused when you first start taking it. Klonopin in clinical trials. Pregnancy and Clonazepam. Free and Confidential. B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

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