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 Theophylline, Aminophylline: (Moderate) Aminophylline has been reported to counteract the pharmacodynamic effects of diazepam. A proposed mechanism is competitive binding of aminophylline to adenosine receptors in the brain. Whether a similar interaction occurs with other benzodiazepines is not known. If aminophylline therapy is initiated or discontinued, monitor the clinical response to benzodiazepines. (Moderate) Theophylline has been reported to counteract the pharmacodynamic effects of diazepam. A proposed mechanism is competitive binding of theophylline to adenosine receptors in the brain. Whether a similar interaction occurs with other benzodiazepines is not known. If theophylline therapy is initiated or discontinued, monitor the clinical response to benzodiazepines.

Tramadol: (Major) Concomitant use of opiate agonists with benzodiazepines may cause respiratory depression, hypotension, profound sedation, and death. Limit the use of opiate pain medications with benzodiazepines to only patients for whom alternative treatment options are inadequate. If concurrent use is necessary, use the lowest effective doses and minimum treatment durations needed to achieve the desired clinical effect. If an opiate agonist is initiated in a patient taking a benzodiazepine, use a lower initial dose of the opiate and titrate to clinical response. If a benzodiazepine is prescribed for an indication other than epilepsy in a patient taking an opiate agonist, use a lower initial dose of the benzodiazepine and titrate to clinical response. Educate patients about the risks and symptoms of respiratory depression and sedation.

 Consequences Of Abusing Clonazepam. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. To reduce the risk of dizzy and fainting spells, do not stand or sit up quickly, especially if you are an older patient. Alcohol may increase dizziness and drowsiness. Avoid alcoholic drinks.

Do not stop taking except on your doctor's advice. You may develop a severe reaction. Your doctor will tell you how much medicine to take. Clonazepam is a controlled substance because it’s possible for people to abuse the drug or become dependent on it. Restless legs syndrome. Abrupt withdrawal, particularly in patients on long-term, high-dose therapy, may precipitate status epilepticus; when discontinuing clonazepam, gradual withdrawal essential; while being gradually withdrawn, simultaneous substitution of another anticonvulsant may be indicated. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). MedicineNet does not provide medical advice, diagnosis or treatment. See additional information.

 Read a self-help book for anxiety based on the principles of CBT (ask your doctor to recommend one) try complementary therapies such as massage and aromatherapy, or activities such as yoga or pilates, to help you relax learn breathing techniques to help ease symptoms exercise regularly to reduce stress and tension it may help to find out more about how to deal with panic attacks try mental health apps and tools from the NHS Apps Library.

More About Drugs and Medications. Anxiety is a feeling of apprehension and fear characterized by symptoms such as trouble concentrating, headaches, sleep problems, and irritability. Anxiety disorders are serious medical illnesses that affect approximately 19 million American adults. Treatment for anxiety may incorporate medications and psychotherapy.

Avoid prolonged use of clonazepam during breast-feeding, and consider alternative shorter-acting drugs, such as lorazepam. Clonazepam is excreted in breast milk in low concentrations with a milk to plasma ratio of approximately 0.3. However, drug accumulation may occur in the infant due to a long half-life. Sedative effects in the infant, with resultant poor feeding, have been occasionally reported with maternal use of clonazepam. Observational studies suggest that benzodiazepine use, including the use of clonazepam, does not prohibit the initiation of breast-feeding, and that continued maternal use may ensue with close monitoring of the breast-fed infant for sedation, poor feeding, problems with weight gain, and apnea; however, more study is needed. Previous American Academy of Pediatrics (AAP) recommendations considered benzodiazepines to be drugs whose effect on the nursing infant is not known but may be of concern, particularly with prolonged exposure. Consider the developmental and health benefits of breast-feeding along with the mother's clinical need for clonazepam and any potential adverse effects on the breast-fed infant from clonazepam or the underlying maternal condition.

An increased risk of congenital malformations associated with the use of benzodiazepine drugs like clonazepam has been suggested in several studies Label 12,14 . There may also be non-teratogenic risks associated with the use of benzodiazepines during pregnancy Label 12,14 . There have been reports of neonatal flaccidity, respiratory and feeding difficulties, and hypothermia in children born to mothers who have been receiving benzodiazepines late in pregnancy Label 12,14 . In addition, children born to mothers receiving benzodiazepines late in pregnancy may be at some risk of experiencing withdrawal symptoms during the postnatal period Label 12,14 . In general, it is best for patients who are of childbearing potential and also use benzodiazepines like clonazepam to discuss such matters with their health care professionals as careful consideration must be undertaken regarding the intersection of the risks of untreated seizure potential in the patient and any possible toxicity to the fetus Label 12,14 . Thiothixene: (Moderate) Thiothixene can potentiate the CNS-depressant action of other drugs such as benzodiazepines. Caution should be exercised during simultaneous use of these agents due to potential excessive CNS effects or additive hypotension.

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