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Depression trials suggest that bupropion is weight-neutral in patients at or below ideal body weight at baseline but is associated with modest weight loss, proportional to initial body mass index. 76, 92 94 In addition, bupropion has demonstrated efficacy as an adjunct for weight loss in nondepressed, obese individuals. 95, 96 The mechanism of the weight-reducing effect of bupropion has not been determined, although it is noteworthy that both dopaminergic and noradrenergic brain pathways have critical roles in the regulation of appetite, satiety, and feeding behavior. 97, 98. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.? With the appropriate monitoring, the risk of abuse or dependency in people who have ADHD is limited,? Adler says. Understanding Cushing's. 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